Diplosol™

For Chronic Pain: Diplosol Says It “All”

Brand new Analgesic

SAY “YES TO DIPLOSOL™, AND “NO” TO PAIN

Chronic pain from rheumatism* doesn’t have to be part of your life anymore.

DIPLOSOL ™

is the trade name for anti-inflammatory/analgesic.
is considered a new chemical entity by the FDA.
is not an NSAID and therefore free of their serious/life-threatening NSAID toxicities.
can be taken for long-term treatment of pain and inflammation which cannot be said for NSAIDS, acetaminophen, or opioids.+
is devoid of the potential liver toxicity associated with acetaminophen (Trade name of Tylenol™).+
is non-narcotic and not habit-forming and therefore unassociated with any of the opioid toxicities.
is known chemically as the salicylic ester of salicylic acid (SESA) and is found in the plant Fissistigma cavalerie**.
active ingredient, 2-hydroxybenzoic acid is also an all plant-based product.
when taken as directed works on pain and inflammation 24 hours per day.
is thought to work via a reduction in excess migration of white blood cells to the site of pain/inflammation.***

*Rheumatism is a group of disorders marked by inflammation or pain in the connective tissue structures of the body. These structures include bone, cartilage, and fat. https://www.cancer.gov/publications/dictionaries/cancer-terms/def/rheumatism

+Hauser TH, Salastekar N, Schaefer EJ, Desai T, Goldfine HL, Fowler KM, Weber GM, Welty F, Clouse M, Shoelson SE,Goldfine AB. Effect of Targeting Inflammation With Salsalate: The TINSAL-CVD Randomized Clinical Trial on Progression of Coronary Plaque in Overweight and Obese Patients Using Statins. 2016. JAMA Cardiol :1 (4): 413-423

**Zaichang Yang, Yule Niu, Yi Le, Xiaoyan Ma, Chong Qiao. Beta-lactamase inhibitory component from the roots of Fissistigma cavaleriei. Phytomedicine 17 (2010) 139–141

***Cronstein B.N., Montesinos M.C. and G. Weissmann Sites of action for future therapy: an adenosine-dependent mechanism
by which aspirin retains its anti-inﬂammatory activity in cyclooxygenase-2 and NFkB knockout mice. Osteoarthritis and Cartilage (1999) 7, 361–363

PDF Resources

SESA structure (salicylic ester of salicylic acid)

DIPLOSOL VS TYLENOL VS ALEVE

Cronstein 1999: How SESA works to fight pain and inflammation

HAUSER 2016; CARDIAC SAFETY

SESA’s active moiety, salicylic acid increases longevity in an animal model of aging.*
*Antioxidants & Redox Signaling · August 2012 .DOI: 10.1089/ars.2011.4151 · Source: PubMed
SESA’s active moiety, salicylic acid can reduce hemoglobin A1c levels and fasting blood sugars in type two diabetics (Goldfine).
SESA’s active moiety, salicylic acid can reduce plasma triglycerides (fatty acids) (Goldfine, Hauser).
SESA’s active moiety, salicylic acid can reduce plasma levels of uric acid (Goldfine, Hauser)..